The concept of frailty, which is a state of increased vulnerability to adverse health outcomes for people of the same age, was developed to explain the heterogeneity in clinical outcomes for older patients ( 3). Because chronological age does not necessarily reflect biologic age, the health status of older adults varies from fit to frail ( 1, 2). Unlike the performance-based eight-item mouse FI, the clinical FI exhibits key features of the FI established for use in humans.Į xperience tells us that people age at different rates. This noninvasive FI based on clinical measures can be used in longitudinal studies to quantify frailty in mice. The exponential relationship between FI scores and age (normalized to 90% mortality) was similar in mice and humans for the clinical FI but not the eight-item FI. FI scores calculated from 70 self-report items from the first wave of the Survey of Health, Ageing and Retirement in Europe were plotted as function of age ( n = 30,025 people). By contrast, the increase was graded with a 31-item clinical FI (0.02☐.005 at 5 months 0.12☐.008 at 19 months 0.33☐.02 at 28 months n = 14). FIs calculated with the original performance-based eight-item FI increased from 0.06☐.01 at 5 months to 0.36☐.06 at 19 months and 0.38☐.04 at 28 months ( n = 14). Here we developed a simplified, noninvasive method to quantify frailty through clinical assessment of C57BL/6J mice (5–28 months) and compared the relationship between FI scores and age in mice and humans.
We previously quantified frailty in aged mice with frailty index (FI) that used specialized equipment to measure health parameters.
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